Overview of our research
Our research focus is to understand the contribution of structural dynamics to the thermodynamics and kinetics of diverse biological processes, such as an autoinhibitory regulation of multidomain proteins, protein-protein interactions, and enzyme catalysis.
To achieve our goal, we combine biophysical, chemical, biochemical, and molecular biology approaches. NMR spectroscopy is our primary tool for structural and biophysical analysis. We also extensively use other techniques, including X-ray crystallography, biolayer interferometry (BLI), isothermal titration calorimetry (ITC), fluorescence spectroscopy. These biophysical analyses are corroborated by sophisticated engineering and tuning of target proteins using semi-synthetic chemical biology techniques, in addition to traditional molecular biology methods.
We are also interested in the development of peptidomimetics as a means of new anti-viral and anti-cancer drugs. We seek a synergistic combination of multidisciplinary approaches.
To achieve our goal, we combine biophysical, chemical, biochemical, and molecular biology approaches. NMR spectroscopy is our primary tool for structural and biophysical analysis. We also extensively use other techniques, including X-ray crystallography, biolayer interferometry (BLI), isothermal titration calorimetry (ITC), fluorescence spectroscopy. These biophysical analyses are corroborated by sophisticated engineering and tuning of target proteins using semi-synthetic chemical biology techniques, in addition to traditional molecular biology methods.
We are also interested in the development of peptidomimetics as a means of new anti-viral and anti-cancer drugs. We seek a synergistic combination of multidisciplinary approaches.